PCOL3012 Lecture Notes - Lecture 2: Medicinal Chemistry, Molecular Geometry, Drug Design

120 views2 pages
25 Aug 2018
Department
Course
Professor

Document Summary

It is extremely electo-negative: can change the way the drug partitions into water soluble or fat-soluble matrices. Binding to a target- shape and intermolecular forces. Saturated rings are not aromatic and have a defined shape (chair or boat) which give it a particular shape. Most drugs represented as 2-di(cid:373)e(cid:374)sio(cid:374)al structures are(cid:374)"t flat: careful control of molecular geometry and shape is crucial in drug design. What determines shape>: isomers (different types, number of electron groups about central atom (valence shell electron pair repulsion) Mitomycin- bound to biosynthetic enzyme: small molecule needs to bind to protein target, e. g. for enzyme target drug binds to active site to stop function of enzyme. Isomers: molecules with the same molecular formula, but with different arrangements of the atoms in space. Geometric (cis-trans) isomers: occurs in molecules with restricted rotation about a carbon- carbon double bond; e. g. 1,2-dichloreothene. Structural isomers: different connectivity of groups. e. g. n-butane, 2-methylpropane.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions