PCOL3012 Lecture Notes - Lecture 8: Nasal Administration, Neuraminidase Inhibitor, Influenzavirus B
Document Summary
Proteins as drug targets: antivirals: approximately, 1500 australians die per year from flu, world-wide, flu affects up to 500 million people per year. Haemagglutinin- entry of viral particles to infect a cell (cell surface recognition) Neuraminidase (ec 3. 2. 1. 18, sialidase, acetylneuraminyl hydrolase) facilitates access of virion to membrane via traversing mucus layer; and important role in exit of viral particles from infected cells. Mechanism of flu virus: 1: nucleocapsid of the flu virus contains (-) singe-stranded rna and viral rna polymerase, nucleocapsid is surrounded by a membrane derived from host cell. This membrane contains two viral glycoproteins that are crucial to the infectious process: (i) hemagglutanin (ha); and, (ii) neuraminidase (na) To access epithelial host cells, virion must negotiate mucus coating mucus is rich in proteins and lipids that contain terminal n-acetylneuraminic acid (sialic acid) residues. Rna polymerase into the nucleus of host cell.
