PHSI2006 Lecture Notes - Lecture 12: Hemoglobin, Bohr Effect, Cyanosis

• School: University of Sydney
• Department: Physiology
• Course: PHSI2006
• Professor: phsi2006

Document Summary

Transport of o2 in blood: some dissolved ( 1. 5% at normal atmospheric pressure, most combined with haemoglobin ( 98. 5%) Pco2, ph acidosis, temperature, 2,3 diphosphoglycerate. ** decrease affinity = shift of o2-hb curve to right = easier unloading o2. O2 carrying capacity of hb at a particular po2 is decreased by increased pco2: easier unloading of o2 in tissues, easier loading of o2 in lungs. Co2 transport in blood: dissolved, combined with haemoglobin, as bicarbonate approx. 83: combination of co2 + h2o produces a weak acid (buffered by hb, effect of o2 on co2 transport: deoxygenated hb is better buffer than hbo2, deoxygated hb has a greater carrying capacity for co2 (haldane effect) Haldane effect: a property of haemoglobin, oxygenation of blood in the lungs displaces carbon dioxide from haemoglobin which increases the removal of carbon dioxide, conversely, oxygenated blood has a reduced affinity for carbon dioxide. Isohydric principle: all buffer systems are in eq. with one another.