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Lecture 8

PHSI3010 Lecture Notes - Lecture 8: Xy Gonadal Dysgenesis, Gonadal Dysgenesis, Labioscrotal Swelling

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Lecture 8: Endocrine regulation of male reproduction 2
DHT drives masculinisation of external genetalia
Effects are mediated by androgen receptor
Oestrogen is not a female-only steroid hormone
Both androgens and oestrogens are important in pathologies of male reproductive tract
Swyers syndrome (XY gonadal dysgenesis)
A type of hypogonadism in a person whose karyotype is 46,XY
Person is externally female with streak gonads
o Streak gonads: defective development of gonads in an embryo, with reproductive tissue
replaced with functionless, fibrous tissue
If left untreated à will not experience puberty
External genitalia form from genital ridge (genital tubercle and labioscrotal swelling)
Masculinisation of external genitalia by androgens is mediated by Wnt signalling
Androgens are essential for masculinisation (Androgen insensitivity syndrome)
o XY individuals
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