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Lecture 7

PHSI3010 Lecture Notes - Lecture 7: Spermatogenesis, Prolactinoma, Fibroblast

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Lecture 7: Endocrine regulation of male reproduction 1
HPG axis modulates endocrine regulation through classic negative feedback of sex steroids
Key mediator is Kisspeptin, also central to establishing GnRH pulse generator during puberty
Androgens & oestrogen synthesis in gonad is determined by organ specific enzymes
Androgens & FSH are essential to spermatogenesis
hTERT allows for spermatogenesis to persist throughout adulthood
Hyperprolactinaemia (presence of abnormally high levels of prolactin in the blood)
Prolactinoma: noncancerous tumor (adenoma) of pituitary gland in your brain overproduces hormone
prolactin (major effect = decreased oestrogen in F, decreased testosterone in M)
Galactorrhea: milky nipple discharge unrelated to normal milk production of breast-feeding
Functional gonadotrophin deficiency with subsequent infertility
Hypothalamo-pituitarygonadal (HPG) axis
1. Testosterone & oestrogen suppress GnRH release
2. Kisspeptin mediates onset of puberty, the establishment of HPG axis & steroid negative feedback
*GnRH is central regulator of reproduction (influenced by many factors)
*GnRH secretion is tonic
*NT/hormones establish the GnRH pulse generator
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