91401 Lecture Notes - Lecture 7: Double Negative, Enzyme, Phospholipid
Document Summary
Genetics of the tcr & the immunological synapse 1. Specialised & architecturally organised microenvironment for developing t cells. T cell development in a nutshell: generates distinct lineages ( (cid:533); (cid:534) ) that express distinct ag receptor genes, extensive selection process (self-mhc--positive selection: addition of cd4/cd8, self-tolerance--negative selection removal of cells that binds too strongly to self. T cell development: thymocytes (cd4 -/cd8 -) [aka lymphoid progenitor cells and double negative cells] give rise to two t cell lineages: (cid:534): t cells (stay double negative: : (cid:533) t cells (become double positive) 95% 8. Recap of t cell receptor structure (cid:534) t cell receptor. Similar structure to (cid:533) tcr but different antigenic properties: (cid:534) tcr: limited diversity, few common gene rearrangements. Adaptive-like" lymphocytes: rag-1 & 2 required (tcr gene rearrangement) Innate-like" lymphocytes: no clonal expansion, no mhc presentation, antigens = unorthodox nucleotides, phospholipids and heat shock proteins.
