300850 Lecture Notes - Lecture 4: Mitochondrion, Calcium Atpase, Hemostasis
Document Summary
Type i > ige, releasing histamine and other mediators. Type iii > igg, but can be igm or iga. Type iv > mediated by t cells rather than by antibodies. There are 2 ways tissue is repaired: complete restitution > loss in the population of labile cells (high turnover), that has now been completely restored, e. g. epider(cid:373)is. Would(cid:374)"t (cid:271)e a(cid:271)le to tell if there was any damage: organisation > when the damage is too deep, which forms a scar. Haemostasis (stopping blood flow) > inflammation > proliferation > maturation. Mechanisms / processes involved in hypoxic and ischaemic injury. Refers to lack of o2 to tissues > oxidative phosphorylation unable to continue > increased rate of glycolysis > pyruvate unable to enter cac > pyruvate reduced to lactate > ph lowered. There"s i(cid:374)(cid:272)reased per(cid:373)ea(cid:271)ility of outer (cid:373)ito(cid:272)ho(cid:374)drial (cid:373)e(cid:373)(cid:271)ra(cid:374)e > cytochrome c leaks into cytosol > apoptosis. Mechanisms / processes involved in hyperthermal, hypothermal and chemical injury.
