300850 Lecture Notes - Lecture 10: Progerin, Portal Hypertension, Portal Vein
Document Summary
Peripheral nerve injuries mechanisms: complete > like cutting with scissors. They are a compound structure at the end of a chromosome. With each cell division, the telo(cid:373)eres get shorte(cid:374)ed. The(cid:455)"re (cid:374)ot repli(cid:272)ated i(cid:374) adults, as it (cid:374)eeds the e(cid:374)z(cid:455)(cid:373)e telomerase, which is inactive in adults. When telomeres become too short, dna polymerase (cid:272)a(cid:374)"t e(cid:374)gage i(cid:374) the start positio(cid:374), (cid:449)hi(cid:272)h the(cid:374) further di(cid:448)isio(cid:374) at so(cid:373)e point becomes impossible. So this is one of the issues responsible for cellular ageing. Progeria a rare syndrome in children characterised by physical symptoms suggestive of premature old age. There is a synergistic relationship between telomere dysfunction and progerin production during the induction of cell senescence, providing mechanistic insight into how progerin may participate in the normal ageing process. Progressive destruction and regeneration of the liver, leading to fibrosis and cirrhosis - will produce insufficient amounts of clotting factors, albumin (causing ascites), etc.
