ANHB1102 Lecture Notes - Lecture 12: Yolk Sac, Blood Vessel, Cell Potency
4 Dec 2018
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Spinning blood separates it into its components. Regulatory function - uid balance, stabilise ph, temp control. Dynamic process - continuous, responsive to acute stimuli eg. infection, bleeding. Yolk sac produces stem cells for rst blood cells. Cell clusters/blood islands form here at wk3 to produce primitive stem cells. Primitive stem cells migrate to mesoderm - agm. Stem cells begin liver, bone marrow, spleen and thymus. Multiplication of stem cells create all blood cells. As age increases, blood cell production rate decreases. Capable of self-renewal (proliferative - to become more of themselves) Differentiate into cells to become more mature cell types + complete their functions. 6th amino acid change in beta chain. Rbc"s clump together and block small blood vessels. Kidney, heart failure, stroke, joint pain, paralysis. 1 hb = 4 o2 molecules ( heme compound binds to oxygen) Monocytes = macrophages + dendritic cells ie. many types w conspicuous nucleus.
