IMED1003 Lecture Notes - Lecture 40: Pyrimidine, Nucleotidase, Phosphoribosyl Pyrophosphate
30 Nov 2018
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Nucleotide metabolism i & ii: understand the basics of nucleotide structure, metabolism and use. Base (purine or pyrimidine) linked to the pentose sugar (ribose or deoxyribose) and phosphate nucleotide. Base (purine or pyrimidine) linked to the pentose sugar nucleoside. Nucleotides and bases in them not only in dna and rna in other components of the cell. Not only in the dna making rnas & proteins. In glycogen synthesis add phosphate or even nucleotide to incorporate other things: cofactors in biochemical reactions e. g. nad+ , nadp, nadph, cell signalling e. g. camp. Pyrimidine: cytosine (c, thymine (t, uracil (u) Dietary nucleic acids: when we eat nucleic acids when we eat animals or plant products. Usually have dna that is associated with proteins e. g. chromatin and chromosomes. There we cleave apart the nucleotides from the protein component. Then have intestinal enzymes made up of rnaases and. We get nucleotides (monomers) and the phosphodiester bonds that are broken.
