IMED1004 Lecture Notes - Lecture 54: Ataxia, Respiratory Failure, Acetaldehyde
30 Nov 2018
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Carbon is non polar, the oxygen is very polar. Physiology of this: basically can go anywhere it wants to, cannot set a concentration gradient as it will just diffuse, will dissolve into the body, and cannot dump out of the body will go where water will go. Reduced inhibitions (more likely to do things that you know is bad) Memory loss (alcohol affects one part of the brain that uses glutamate in hippocampus hence do not form memories) Toxic- spreads through the body hence can be measured by-- 100 ml blood: set because good look at physiological effects increase in alcohol, effects get worse. <10% is directly excreted: breath, sweat, urine, tears (2-3%, diffusion gradient problems. >90% is removed by oxidation (liver alcohol is taking out metabolically by the liver: first pass metabolism series of reactions, ethanol to acetaldehyde and then to acetate (bengign, most of it is this, to detoxify the blood.
