BIOL 3553 Lecture Notes - Lecture 20: T Helper 17 Cell, Mhc Class Ii, Mhc Class I
Document Summary
Type iv hypersensitivity delayed type hypersensitivity (dth) Caused by activation and proliferation of antigen-specific t cells. T cells are activated by contact with apcs are release inappropriately large amounts of cytokines. Recruitment and activation of monocytes and macrophages are responsible for deleterious outcomes. Chemicals that interact with the skin can change how the cells look and make them look foreign so your body will mount an immune response to it. General characteristics of dth: events leading to dth reactions: activation of antigen-specific inflammatory th1 and th17 cells in a previously sensitized individual, production of pro-inflammatory cytokines by proliferating antigen-specific th1 and. Th17 cells: recruitment and activation of inflammatory leukocytes that are not specific to antigen. These events occur over a period of 48-72h. Antigen processed by local dc (dendritic cells in the skin langerhans cells) Dcs present peptide on mhc ii and mhc i. Antigen specific th1, th17 and tc cells proliferate.
