PSY3710 Lecture Notes - Lecture 6: Phospholipid, Phospholipase C, Glycerophospholipid

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Overview (differences and similarities, in lipids composition and synthesis, of prokaryotic and eukaryotic membranes) Recall the species and tissue differences in weight percentages of total lipids. Prokaryotes and eukaryotes (yeast and mammals) have slightly different overlapping strategies for phospholipid synthesis. In eukaryotes, lipid synthesis occurs using cytosolic and er membrane- bound enzymes and involved subsequent trafficking. Incorporation of fas into membrane lipids takes place on er membranes and steps are catalyzed by membrane- associated enzymes: phosphoglycerides (=glycerophospholipids) The first thing that the cell does is generate molecules for glycerol phospholipid biosynthesis. Membrane- bound enzymes on cytosolic side of smoother er (or bacterial membrane) Glycerol- 3- p -> (coash, acyl- coa, acyltransferase) -> phosphatidase (pa) Pa is common intermediate from which derive dag. Pa is a precursor of both triacylglycerols and glycerophospholipids. Dag is a common intermediate for the latter. There are 2 strategies for attaching headgroups. The 2 strategies for attaching headgroups: #1 in prokaryotes and eukaryotes, #2 in eukaryotes.

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