BCHM 3P01 Lecture Notes - Essential Amino Acid, Ketone Bodies, Phenylalanine
20 May 2014
School
Department
Course
Professor
Document Summary
Phill of mtv (phe, his, iso, lys, leu, met, trp, val) Alpha-keto acid is essentially a naked amino acid. Amino acids are precursors of glucose, fatty acids, ketone bodies. Deamination-removal of the amino group to release ammonia or transfer it onto a keto acid nitrogen urea cycle intermediates. Incorporation of ammonia and aspartate nitrogen into urea gets rid of excess. Can transfer to make glutamine or aspartate o. Conversion of the amino acid carbon skeleton to common metabolic. Overall, when amino acids are broken down, the amino group is removed, converted into urea for excretion if there is an excess of nitrogen, and the remaining carbon skeleton is degraded. L-aa1 + -keto acid 2 -keto acid1 + l-amino acid 2. Amino transferases are specific for the amino acid donating the amino group. However, the acceptor -keto acid is -ketoglutarate or oxaloacetate which accepts the amino group. Most amino acids funnel their amino groups into glutamate.
