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Class Notes for Biochemistry at Brock University

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BCHM 3P01 Lecture Notes - Lecture 1: Neurodegeneration, Starch, Catabolism
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BROCK UNIVERSITY DEPARTMENT OF BIOLOGICAL SCIENCES BCHM 3P01 Metabolic Biochemistry, Winter 2018 Instructors: Dr. Aleksandar Necakov, MCF 239, anecakov@brocku.ca Office Hours: Tues 1011:30; or by appointment (email in adva...

Biochemistry
BCHM 3P01
Aleksandar Necakov
Introduction to Metabolism.docx

Introduction to MetabolismJanuary0714754 AMReadings Chapter 1 2 and 4What is metabolic biochemistryHow organism stores and use energyHow a cell utilizes energy to break down and build compounds within the celloHow does tha...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Acetyl-Coa, Futile Cycle, Pyruvic Acid

ThermodynamicsMarch1114828 AM Outline IntroductionFree energyFree energy and standard free energyEnergy coupling coupled reactionsThermodynamics of glycolysisIntroductionHypothetical reactionA B Questions we often ask Does...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Sucrose, Glycogen, Amylose

Sucrose and Starch Synthesis BCHM 3P01January3014756 AM Glycosidic BondsAllows for multiple subunits to be joined togetherMonosaccharides are joined to other monosaccharides or to alcohols and Amines through glycosidic bon...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Reduction Potential, Photosynthetic Reaction Centre, Acetyl Group

Redox Reactions and Oxidative PhosphorylationJanuary1414754 AMGlobal warminghas been damaging our earthGoal to use the suns energy to make liquid fuel for usPhotosystem two is very delicate 5 degrees and in the darkUse all...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Light-Independent Reactions, Glycolic Acid, Epimerase And Racemase

The Dark ReactionsJanuary2414755 AM Inoxygen photosynthesis you generate ATPNADPH has a high reducing power going to use this to fix carbonNeed photosynthesis to make the cofactors for this reactionDoes glycolysis in the d...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Colipase, Ketone Bodies, X-Ray Crystallography

Fatty Acid MetabolismMarch2014754 AMLarge carboxyllic acid groups Saturated vs unsaturated More soluble in MeOH or chloroform than in water Saturated0 double bonds Unsaturated1 double bond Polyunsaturated1 double bondAlmos...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Citric Acid Cycle, Acetyl-Coa, Cellular Respiration

Citric Acid CycleFebruary2714826 AM Glucose oxidation is what fuels metabolism So far in the course have we oxidized glucose Glucose2 pyruvate Is this the most oxidized state of glucose Can we go furtherNo we can go to car...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Light-Dependent Reactions, Light-Independent Reactions, Photosynthetic Reaction Centre

The Calvin Cycle and ReviewJanuary2814757 AMThe Calvin CycleFirst we make phosphoglycerate from Carbon dioxide and riboluse 15 bisphosphateThis is one of the dark reactionpH goes up in the stroma when the light reactions a...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Essential Amino Acid, Ketone Bodies, Phenylalanine

Amino Acid MetabolismMetabolic IntegrationApril0114800 AM Overview of Amino Acid Metabolism What are amino acids used for Protein synthesisHormone precursorsNeurotransmissionHeme factorsNucleotides mostly the basesCoenzyme...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Pyruvic Acid, Exergonic Process, Catabolism

BCHM 3P01 Glycolysis and FermentationChapters 1617February0614802 AMBreak glucose into pyruvate used in the citric acid cycle main goal of glycolysis Free Energy Change and Spontaneous Exergonic Reactions ABCDPutting in a ...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Glycogen, Hydrolysis, Phosphorylase

Glycogen MetabolismFebruary2514801 AMReview Glycogen Polymer of glucose D or L What are the bonds called that link together glucose units in a polymerGlycoside bondsWhat specific bonds are seen in glycogen Alpha14 makes th...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Gluconeogenesis, Glycogen, Cellular Respiration

Gluconeogenesis and Glycogen MetabolismFebruary1314800 AM GluconeogenesisSynthesis of new glucoseNot the reverse of glycolysisRunning through an independent pathwayThree or four key enzymes that arent in glycolysisNoncarbo...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Steric Effects, Enolase, Dehydration Reaction

BCHM 3P01 Feb 7 20147 Phosphoglycerate Kinase First ATP generation for every 1 glucose this happens twice Phosphoryl transfer of acyl phosphate of 1 3 biphosphoglycerate to ADP ATP formation referred to as substrate level ...

Biochemistry
BCHM 3P01
Nicholas D Vesprini
BCHM 3P01 Lecture Notes - Acetyl-Coa, Futile Cycle, Rate-Determining Step

ThermodynamicsMarch1114828 AM Outline IntroductionFree energyFree energy and standard free energyEnergy coupling coupled reactionsThermodynamics of glycolysisIntroductionHypothetical reactionA B Questions we often ask Does...

Biochemistry
BCHM 3P01
Nicholas D Vesprini

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