BIOL 1F25 Lecture Notes - Lecture 5: Blood Vessel, Angiogenesis, Cell Migration

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Human embryonic development requires lots of cell division, blood vessel development, cell migration, cell death and tissue invasion. These processes are tightly controlled by genes. Cancer is characterized by abnormal use of these processes due, as we shall see, to mutation of the genes that are required for development. We would observe a linear response, if the probability did not develop with age: if the probability was constant, if we only look at one event. Two possible reasons: many changes to normal cells are required for cancer development, the probability of a single event increases over time. There is a change in cell shape. As cancer develops, tissue becomes disorganized; loss of structure. Stage 0: in situ (localized) cancer with few abnormal cells: very small tumors. Stage 1: cancers are localized to one part of the body. Stage 3: cancers are also locally advanced.

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