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Lecture 19

Lecture 19

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Daniel Glenday

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Outline of Lecture 19 Sex Determination and DifferentiationIEmbryologic origin of the reproductive systemth At 4 week intermediate mesoderm gives rise to mesonephros the mesonephric Wolffian ducts give rise to epididymis and vas deferens in maleth At 6 week intermediate mesoderm give rise to paramesonephric Mllerian ducts which give rise to oviducts and uterus in female Hox genes are involved in AP patterning of urogenital tract Primordial germ cells Arise in primitive streak and endoderm migrate to yolk sac then back to genital ridge Migration requires Steel factor In females number of germ cells spikes the quickly falls in fetus and experiences steady decline throughout life in males number of germ cells are constantly renewed Can be used as a source of embryonic stem cells Fate of PGC male G arrest female prophase I arrest in embryo is determined 1by environment but postnatal fate depends on genetic makeupIIControl of sexual development gonadal sexphenotypic sexA It is a sequential process genetic sex B
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