BIOL 1F25 Lecture Notes - Lecture 3: Pipette, Axon Terminal, Central Nervous System
Document Summary
Development of the central nervous system (cns) of mammals: roughly 10,000 synpases formed in as short a time as 15 minutes. During development, it is essential that the growing axons of neurons find their way to the correct region of the brain. Once there, they need to identify and connect with the correct targets. During development, growing end of axon called a growth cone. Studied mainly in cultured neurons (grown in a dish) Filopodia: the fine, hair like structure that sense the environment (main sensors of the growth cone) Example of two non-synaptic partners i. e. do not make connections in the intact brain. When re-growth in cell culture, they remember which cells to connect with. They send repulsive messages to each other. When receiving a repulsive signal, growth cones may not be able to turn, but show a (cid:862)(cid:272)ollapse(cid:863) (cid:271)eha(cid:448)iour (cid:449)here it (cid:271)alls up and pulls a(cid:449)ay. Example of two synaptic partners: do make contact in intact brain.