BIOL 1F25 Lecture 12: BIo Lec 12
9 Mar 2017
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Document Summary
Bio lecture 12 - nov. 9,2016 two identical alleles of a gene are required for the production of any human trait twice as much altered tumour suppressor protein is needed for cancer development. Q: the contribution of a tumour suppressor gene to cancer involves two mutations because: alleles of tumour suppressor genes which contribute to cancer are recessive. 2: alleles of tsg which contribute to cancer are dominant. Both copies of a tumour suppressor gene must be mutated for that gene to contribute to cancer. On average, 6 to 7 mutations of tumour suppressor genes and proto-oncogenes are observed in cancers. Most normals cells encodes the genes, stop producing telomerase. Approach: transfect normal cells( not immortal) with active htert gene or with a gene that activates the inactive htert gene. Based upon info of the roles of rb and p53 genes in apoptosis, they also tested the effects of these genes on conversion to immortality.
