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Lecture 17

BIOL 1F25 Lecture Notes - Lecture 17: Transcription Factor, Methyl Benzoate, Biosensor

Biological Sciences
Course Code
Gaynor E Spencer

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Nov 13th 2015
LEC 17
The Link Between Learning And Memory And Drug Addition
Dec 19th exam
100 multiple-choice questions
82-85 questions will be on dr. spencer
The rest will be dr. Mercier
All questions are on ONLY LECTURE MATERIAL
Everything from the slides
Dr. Vesprini and Rothwell guest lecture will be on the exam
Associative memory.
Addict associates a cue with taking the drug.
Memories of places/ people (context cues) etc. can trigger relapses in cocaine use.
Result of classical conditioning.
Plays a role in abuse potential.
Stimuli associated with cocaine use can evoke cravings
Dopamine signaling involved again!
Stimuli associated with prior cocaine use have “priming effect”
Suggested to increase release in dopamine in NAc in absence of cocaine.
Associative learning:
Classical conditioning: brain makes association b/w 2 unrelated stimuli
Important area of brain involved in learning and memory: hippocampus
Hypothesis: learning and memory mechanisms play important roles in lasting
alterations induced by cocaine.
The hippocampus has connections with NAc and prefrontal cortex (i.e. reward pathways).
NAc receives glutamate input from hippocampus
LTP can also occur at glutamate synapses in NAc.
i.e. strengthening of connections between hippocampus and reward pathway.
Evidence: cocaine modifies LTP in hippocampus:
Behavioral data from rats: stimulation of hippocampus can induce cocaine relapse
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