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Lecture 13

BIOL 1F90 Lecture Notes - Lecture 13: Symporter, Conformational Change, Hydrophile


Department
Biological Sciences
Course Code
BIOL 1F90
Professor
Fiona Hunter
Lecture
13

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Lecture 13- finishing chapter 6, start of chapter 7
October 6, 2015
Transporters
Transporters: Bind their solutes in a hydrophilic pocket and undergo a
conformational change that switches the exposure of the pocket to the
other side of the membrane
Uniporters: Bind a single molecule or ion and transport it across the
membrane
Symporters or cotransporters: Bind two or more different types of ions
or molecules and transport them in the same direction
*More solute the fast it will travel, at first when you increase solute concentration
it will go faster but then reach a maximum speed velocity (rate) (saturated
concentration)- when everyone is paired

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Antiporters: Bind two or more different types of ions or molecules and
transport them in opposite directions (revolving door)
Pump: Type of transporter protein that directly couples its conformational
changes to an energy source (uses energy (ATP), to grab a solute
molecule and put it where it doesn’t want to go, take it from a place of low
concentration and put it to a concentration where it is high)
ATP-driven pumps: Common category of pumps that is found in all living
cells which have a binding site for ATP
-Figure 6.22 (transporters that function as pumps) slide 47
-Calcium pump, eventually it will reach a max amount of calcium
-Used to keep calcium concentration low in the cytoplasm
-Primary active transport
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