BIOL 1F90 Lecture 12: BIOL 1F90 lecture 12 winter 2016

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Randomly eliminated members without regard to genotype. Surviving members may have allele frequency di erent from original population. Now population likely to have less genetic variation. Small group of individuals separates from a larger population and establishes a new colony. Relatively small founding population expected to have less genetic variation than original population. Allele frequency in founding population may di er markedly from original population. Much of variation seen in natural population ins caused by genetic drift. Most genetic variation is due to the accumulation of neutral mutations that have attained high frequencies due to genetic drift. Neutral mutations do not a ect the phenotype so they are not acted upon by natural selection. Main idea is that much of modern variation in gene sequence is explained by neutral variation rather than adaptive variation. Nucleotide substitutions much more likely in third base of codon (usually doesn"t change amino acid) than rst or second (usually does change amino acid)

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