BIOL 2P02 Lecture Notes - Lecture 27: Alternative Splicing, Calcitonin Gene-Related Peptide, Primary Transcript
14 Dec 2016
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Process of removing intron from mrna is constitutive mrna splicing. An intron is not always an intron. Alternative splicing: the process by which one gene can generate multiple mrnas by differential splicing of the primary transcript (figure 16-8, phenomenon of mrna splicing where the spliceosome decides which will be an exon or an intron. You can have the same gene sequence (non-coding and coding sequence) Spliceosome decides that exon 2 is an intron (alternative figure) Splicing and adenylation are different: one gene can make more than one protein (can be similar proteins in a large amount) Out of 20500 genes, each gene can make more than 1 protein. Based on the fact that humans make more alternative transcripts on the gene than any other organism. Can have at least 4 different proteins per gene. Thus one gene can encode more than one protein. Proteins are similar but not identical and may have distinct properties.
