BIOL 2P02 Lecture Notes - Lecture 23: Homologous Chromosome, Ribosomal Rna, Mitosis
14 Dec 2016
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Dna double-strand break (dsb repair: lost information, undergoes homologous recombination (hrs, has 2 crossover points. Process (figure 13-2: end-p(cid:396)o(cid:272)essi(cid:374)g (cid:272)(cid:396)eates 3" o(cid:448)e(cid:396)ha(cid:374)g expose single stranded dna. Helicases and nucleases: first strand invasion activity infiltrates other homologous chromosome. Recombinase: second strand invasion has a template for both strands. Homologous recombination is an obligatory phenomenon during the formation of mitosis: make hybrid chromosomes all the time suppressing this is really negative, happens when we make gametes and daughter cells. Figure 13-3: dissociation then more dna synthesis and ligation, ligation takes place while it is still linked, during meiosis and mitosis, there are no gaps; have intact sequences results in holiday junctions (intermediates of recombination) Depending on where you cut it (crossover strand or the other strand) Transcription is the first step of gene expression. All rna molecules are derived from information stored in dna (with some exceptions: exceptions: female gonad containing rna (not tested on this)
