BIOL 2P03 Lecture Notes - Lecture 6: Pyruvate Dehydrogenase, Cardiac Muscle, Skeletal Muscle

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11 Feb 2016
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Biol 2p03 Energetics
Lecture 6
Major types of metabolic fuels catabolized by animal cell to produce ATP
ATP is a central intermediate between catabolic and anabolic pathways
ATP
-is not stored, it is continuously synthesized and hydrolyzed as the cell imports
oxidizable fuels
-major ATP producing pathways are (glycolysis-little ATP) and oxidative
phosphorylation-lot of ATP
Glycolysis
-partial oxidation of 1 glucose molecule (6 carbon) to 2 molecules of pyruvate (3
carbon)
-occurs in the cytosol
Fermentation
-under some conditions, including low oxygen but high growth conditions, pyruvate
produced won’t be completely oxidized in the mitochondria
-yeast can ferment glucose to ethanol
-in animal cells glucose is fermented to lactic acid
Malate-aspartate shuttle transfers reducing equivalents(NADH) formed in the
cytosol into mitochondrial matrix
*Complete oxidation of pyruvate
-in mitochondria, releases 3xC02
-leads to lots of ATP produced
Pyruvate dehydrogenase
-associated with inner face of inner membrane
-catalyzes pyruvate acetyl-coA + CO2
Citric acid cycle
In the mitochondria, begins with acetyl-coA
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