Control of ECF V (Diuretics)

Control of ECF & Composition V Diuretics I. Intro a. Terms i. Diuretic—an agent that increases urine flow rate by inhibiting reabsorption of solutes & H2O ii. Edema—increase in fluid in interstitial space iii. Diuretic Rebound—phenomenon that occurs when one stops taking diuretics and see even more accumulation of ISF than before diuretic use (due to compensatory mechanism) b. Heart Failure—as heart begins to fail → blood pools in veins → baroreceptors sense ↓ venous return (↓ fluid) → kidneys retain more fluid → ↑ venous pressure & congestion → buildup of ISF * diuretics => ↑ fluid excretion! II. Classes of Diuretics a. Hydrogen Transport Inhibitors (Carbonic Anahydrase Inhibitors) i. Work in proximal tubule