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BIOL 2P94 (40)
Lecture

Lecture 06

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School
Brock University
Department
Biology
Course
BIOL 2P94
Professor
Dirk De Clercq
Semester
Fall

Description
Outline of Lecture 06 (02-19 B; Linden) Synaptic Transmission I. Ca couples action potential depolarization to neurotransmitter release - Whereas Na and K help propagate an action potential, Na and K current are not necessary at the presynaptic terminal for nxt release - Evidence: Depolarization with TTX and TEA blockage of Na and K channels still results in nxt release - Voltage-gated Ca channels and Ca current are necessary for nxt release - Evidence: numerous, e.g. removal of Ca blocks nxt release, Ca flood causes nxt release - Ca promotes fusion of synaptic vesicles with presynaptic membrane - Candidate interactions: synaptotagmin (particularly), calmodulin, PK-C - Since nxt is stored in discrete vesicles of uniform size, nxt release is quantal and not graded II. Neurotransmitters that affect ion channels cause predictable excitation or inhibition - Nxt bind postsynaptic receptors and (1) open/close an ion channel or (2) modulate enzyme st act
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