BIOL 2P94 Lecture Notes - Long-Term Potentiation, Excitatory Postsynaptic Potential, Synaptic Plasticity

51 views1 pages
Published on 4 Feb 2013
Course
Outline of Lecture 28 (02-26 D; Baraban)
Synaptic Plasticity
I. Long term potentiation
- LTP is the phenomena that the peak excitatory post-synaptic potential (epsp) to low-frequency
input is greater after a high-frequency input (tetanus), and that this effect persists for a long time
- Of presyn, postsyn, or both, most people believe postsyn changes mediate LTP
- LTP is a bistable switch toggled by NMDA
- AMPA receptors require Glu for to open and do not allow Ca flux
- NMDA receptors require Glu and depolarization to open and allow Ca flux
- Mechanism of toggling: tetanus prolonged depol. AMPA nad NMDA opens Ca flux
due to NMDA signals for insertion of more AMPA receptors greater postsyn depol
in future
- “Silent” synapses with no AMPA can still undergo LTP if NMDA receptors are still present at
synapse and if surrounding synapses provide depol. for NMDA activation
- Two major properties of LTP
- Input specificity: only synapse receiving tetanus gets LTP
- Associativity: (however) a weak input at another synapse at the same time as a strong input at
another provides depol. to the former and causes LTP at both
- The broader picture
- LTP provides a mechanism to begin explaining learning and memory
- Associativity provides a simplistic mechanism to explain Pavlovian conditioning
II. Long term depression
- LTD can result in un-learning, and decrease in synaptic efficiency but is not well understood
III. Other forms of synaptic plasticity
- Dendritic spines: addition or deletion, shape changes
- Genetic defects in NMDA receptor function/regulation are linked to schizophrenia
Summary of major points
- See Objectives on p. 1
- There really isn’t much in this lecture beyond LTP
Unlock document

This preview shows half of the first page of the document.
Unlock all 1 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.