BIOL 2P94 Lecture Notes - Dlg4, Transamination, Neuroprotection

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Outline of lectures 17 (02-21 d; snyder) and 21 (02-24 c; snyder) Amino acids: gaba: the principal inhibitory neurotransmitter. Synthesis: decarboxylation of glu (nerve terminal) or by transamination (in mito) Gaba inactivated by reuptake by ensheathing glia. Multiple binding sites particularly benzodiapine site (valium is agonist, allosteric with gaba) and barbituate (target of sedatives, and perhaps alcohol) Found in the cortex and inhibited by bicuculline (compare to gly) Gaba-b receptor: metabotropic autoreceptor, inhibitory via opening k channels or ca conductance, drug target of baclofen. Although gly is found in nerve terminals throughout cns, gly receptors are found primarily in spinal cord and are inhibited by strychnine and not bicuculline (see gaba-a) Gly found in interneurons that inhibit motoneurons; drug mimics are good muscle relaxants. Synthesis: from gln or transamination, the nxt pool is unclear; highly abundant aa. Glu acts on presyn and postsyn, inactivated by reuptake by glia and neurons. Ionotropic, lets na in and k out, depolarizing and excitatory.

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