BIOL 2P94 Lecture Notes - Lecture 6: Corpus Callosum, Lesion, Paraphasia

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Outline of Lecture 60 (03-25 B; Hillis)
Aphasia
Speech Compre-
hension
Repetition Lesion Blood
Broca’s Telegraphic Relativel
y good
Fair, telegraphic Left posterior
inferior frontal
Left superior
MCA
Wernicke’s English-like but
empty in
meaning, may use
neologisms
Poor Severely
impaired
Posterior, superior
temporal cortex
Left inferior
MCA
Conduction Fluent,
paraphasic,
conduit
d’approche
Relativel
y good
Poor, maybe as a
result of loss of
short-term
auditory memory
Classically,
arcuate
fasciculous
(disconnect bet.
Broca’s &
Wernicke’s areas)
Transcortical
Motor
Nonfluent,
telegraphic
Good Fluent, much
better than
spontaneous
speech
Left dorsolateral
frontal
Left ACA or
watershed
between ACA
and MCA
Transcortical
Sensory
Fluent,
paragrammatic
Poor Much better
than
spontaneous
speech
Temporo-occipital
junction
Watershed
between MCA
and PCA
Mixed
Transcortical
Nonfluent Poor Echolalic Complex Watershed
between left
ACA/MCA or
MCA/PCA
Global Limited to a few
words
Poor Poor, like speech Both Broca’s &
Wernicke’s area
Entire left
MCA
Anomic Fluent,
grammatical;
impaired word
retrieval
Intact Intact Posterior inferior
temporal gyrus
Left MCA
Optic Normal and
normal naming
Good, but
impaired
picture
ID
Left occipital or
splenium of
corpus collosum,
disconnect
between vision
and language
Comments on correlates with lesion sites and vascular supply
- Best correlations are with specific language tasks and lesion sites (not aphasia syndrome and
lesion site)
- Some language tasks, like picture identification, are performed by a network of relatively
discrete regions of the cortex; lesions at any part of the network may produce a defect in that
language task
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