BIOL 3P43 Lecture Notes - Lecture 30: Antibiotics, Competitive Advantage, Peptidoglycan
17 Mar 2019
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08/03/2019: actinomyces are important originally thought to be fungi but they are bacteria that grow in filamentous strands. Penicillin: first antibiotic found in 1929 by flemming, effective against, sore throats (strep throat, pneumonia, skin infections, wound infections, scarlet fever, extremely toxic to invading organisms with little to no effect on host. 08/03/2019 conidia structures: found as contaminant on plate of staphylococci, commercially available during wwii (1946) 08/03/2019: 1) e. coli cells that are untreated, 2-4) various time treatments with beta-lactam antibiotics. If treated with the antibiotics, they look as if something is popping out the integrity of the cell structure is maintained by the peptidoglycan and underneath there is an inner membrane. The antibiotics destroy the structure of the peptidoglycan and the cell interior bulges out blebbing: peptidoglycan is no longer cross linked, produced by a secondary metabolite, cells will shunt some of the primary metabolites.
