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Lecture 6

HLSC 4P95 Lecture Notes - Lecture 6: Arachnodactyly, Mucopolysaccharidosis, Blood Pressure


Department
Health Sciences
Course Code
HLSC 4P95
Professor
B Jeynes
Lecture
6

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Midterm: Need a pencil, 1 hour, 40 M/C questions, spread evenly, mostly in the lectures. BIG PICTURE!
Zygote (single cell, all the genetic information present)
Morula (cluster a cell)
Blastocyst (hollow sphere)
Germ layers (primordia)
Organogenesis
Fetus
Normal Development
Sensitivity Stages
Eyes, heart, extremities, eyes, external genitalia is already underway in the 1st trimester
Pathogens, abused drugs ect.
1st trimester where things are sensitive to genetic and environmental factors
As the cell divides to make systems
*See pie chart in textbook*
What we know about disease cause is largely unknown or understood
Minor (cleft lip)
Major (spontaneous abortion)
Genetic factors
Irraditation (x-ray, gamma, beta, alpha)
Physical
Industry, FAS, thalidomide, opioids
Chemical
Toxoplasma (parasite)
Other (Epstein-Barr virus)
Microcephaly
Heart disease
Rubella (virus)
Cytomegalovirus (CMV)
Herpesvirus
TORCH***
Microbial
Exogenous teratogens
Developmental Malformations
Genetics Structures
44 to 2
Autosomes and Sex Chromosomes
Deletion
Translocation
Structural
Diploid
Death
Monosomy (-1)
Sex chromosome (life)
Common characteristics
Trisomy 21 (Down's syndrome-meiotic disjunction)
Autosome (13, 18, 21) can be lethal in utero but not always
Trisomy
Aneuploidy- not diploid
Numerical (autosomal/sex)
Chromosomes Abnormalities
Genetic and Developmental Diseases
February-12-15
2:00 PM
CHSC 4P95 Page 1
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