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Lecture 4

CHSC 4P99 Lecture 4: Diagnosis III.pdf

by OneClass279660 , Winter 2015
1 Page
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Department
Health Sciences
Course Code
HLSC 4P99
Professor
Brent Faught
Lecture
4

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Exam: logical cut off point or positivity criteria
Receiver Operator Characteristic Curve
The yellow line is the reference line
If the sweet spot is hit, then you would have a perfect sensitivity
If there was 100% sensitivity and specificity, it would be a gold standard
Pick a spot on the curve that we are happy with
PICK THE CUT OFF BASED ON THE SEVERITY OF THE DISEASE
It's important to identify who don't have the disease (specificity)
Carpal tunnel
Somewhere in between
If your ROC lies on the reference line, it's a coin toss
Above the line increases accuracy
Accuracy
Extra area under the curve
Pick this one
AUC- area under the curve
Analysis
Example: *see phone*
Exam: if the ROC curve is under the line, you calculated it wrong.
When it's a condition that's in the middle, sensitivity and specificity are both
important
What is the noise in the two by two? The false positive and negative (not their
rates). Add these together and compare to the noise of the other one. The one
with the least amount of noise is the right one
You can get likelihood ratios from it.
Sweet spot
Diagnosis III
February-03-15
2:02 PM
CHSC 4P99 Page 1

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Description
Diagnosis III February-03-15 2:02 PM Exam: logical cut off point or positivity criteria Receiver Operator Characteristic Curve Sweet spot • The yellow line is the reference line • If the sweet spot is hit, then you would have a perfect sensitivity • If there was 100% sensitivity and specificity, it would be a gold standard • Pick a spot on the curve that we are happy with • PICK THE CUT OFF BASED ON THE SEVERITY OF THE DISEASE • It's important to identify who don't have the disease (specificity) ○ Lumbar perfusion (invasivesurgery) • Somewhere in between ○ Carpal tunnel Analysis
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