HLSC 2P09 Lecture 5: Lecture 5
14 Feb 2017
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Document Summary
Signaling through 7 tm receptors : g-protein- adenylyl cyclase. !1: signal molecule binds to g protein-linked receptor, which activates the g protein. Ip3 causes release of ca2+ from organelles (er), creating a ca2+ signal (increase in calcium intracellular which leads to change in signal) ** gtp and plc are plasma membrane bound ** Signaling molecules regulating ion channels: receptor-channels open or clase in response to signal molecule binding, some channels are directly linked to g proteins, other ligand-gated channels respond to intracellular second messenger. Release into cytosol: ca++ channels in pm, voltage gated ca++ channels in pm ip3 gated ca++ channels in er (main calcium storage of calcium) ryanodine receptors in sr. ++ / mol protein) activation of cam -dependent protein kinases which phosphorylates proteins: troponin c (4 mol ca++ / mol protein) initiation of muscle contraction free ca+, activation of pkc, exocytosis (insulin release)
