Class Notes (1,017,848)
CA (584,791)
Brock U (12,936)
NEUR (32)
Lecture 4

NEUR 2P37 Lecture Notes - Lecture 4: Protein Synthesis Inhibitor, Long-Term Potentiation, Nmda ReceptorPremium

5 pages21 viewsWinter 2017

Department
Neuroscience
Course Code
NEUR 2P37
Professor
nickslothouber
Lecture
4

This preview shows page 1. to view the full 5 pages of the document.
NEUR2P37
Brain and Behaviour II
Wednesday, January 25th ,2017
Lecture #4
MEMORY III
The Mechanisms of Memory
General Mechanisms of Learning and Memory
- Memory involves widespread activity in the brain
- There are general principles of plasticity that apply to all regions
- All models of memory include changing the strength of the synaptic connection based on
previous activity
Memory as a Synaptic Change
- Donald Hebb hypothesized about experience-dependent plasticity
- Cells that fire together ill ire together He’s idea
- Basically if cell A repeatedly stimulates cell B, then the connection between A and B is
strengthened.
find more resources at oneclass.com
find more resources at oneclass.com
You're Reading a Preview

Unlock to view full version

Subscribers Only

Only half of the first page are available for preview. Some parts have been intentionally blurred.

Subscribers Only
Synaptic Mechanisms of Learning and Memory
- Molecular events that appear to underlie learning and memory
(Hebb; Changes in synaptic efficiency are the basis of LTM)
(Long- term potentiation (LTP); synapses are effectively made stronger by repeated stimulation)
Long-Tem Potentiation and Depression
- Long-term potentiation (LTP) was the first demonstration of the experience dependent
plasticity proposed by Hebb
- LTB was first described in 1973, about 25 years after it was proposed by Hebb
- Long-term potentiation of a synapse in the hippocampus. The baseline rate (time=0 hours) of
synaptic activity was set at 100%
- The resulting increase in firing rate (up to 300% of baseline) remained for up to 10 hours.
find more resources at oneclass.com
find more resources at oneclass.com
You're Reading a Preview

Unlock to view full version

Subscribers Only

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.