NEUR 2P37 Lecture Notes - Lecture 4: Protein Synthesis Inhibitor, Long-Term Potentiation, Nmda Receptor
25 Jan 2017
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Document Summary
Memory involves widespread activity in the brain. There are general principles of plasticity that apply to all regions. All models of memory include changing the strength of the synaptic connection based on previous activity. Cells that fire together (cid:449)ill (cid:449)ire together (cid:894)he(cid:271)(cid:271)"s idea(cid:895) Basically if cell a repeatedly stimulates cell b, then the connection between a and b is strengthened. Molecular events that appear to underlie learning and memory (hebb; changes in synaptic efficiency are the basis of ltm) (long- term potentiation (ltp); synapses are effectively made stronger by repeated stimulation) Long-term potentiation (ltp) was the first demonstration of the experience dependent plasticity proposed by hebb. Ltb was first described in 1973, about 25 years after it was proposed by hebb. Long-term potentiation of a synapse in the hippocampus. The baseline rate (time=0 hours) of synaptic activity was set at 100% The resulting increase in firing rate (up to 300% of baseline) remained for up to 10 hours.
