KINE 2P97 Lecture 6: KINE 2P97 (6)

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KINE 2P97
Muscle Physiology & Exercise Metabolism
TCA Cycle
- Tricarboxylic Acid Cycle, Aka Kes Cle, Aka Citric Acid Cycle
- Substrate: Acetyl-CoA
- Poduts: CO, ATP ad eduig euivalets
o NADH and FADH2
- Metabolizes Acetyl-CoA Produced from all three macronutrient pathways
- X fo eah 6C gluose o gluose fo gloge oleule
- X times for each fatty acid (variable length carbon chain)
Cycle I: Synthesis of Citrate (6C)
- CS has very high activity
- Use as a biochemical marker of aerobic capacity
Cycle II: Molecule Reorganization
- Reorganization of oxygen and hydrogen
Cycle III: Reduction of Isocitrate
- Produces CO2 and first NADH + H+
- Remember what dehydrogenase does
IV: Further Reduction
- produces CO2 and another NADH + H+
V: Production of ATP equivalent
- GTP is converted to ATP (same thing)
- So GTP~ATP
VI: Reduction of FAD
- Produces FADH2
VII: Molecule Reorganization
- Reorganized
VIII: Fial ‘edutio ‘eatio
- Final NADH + H+ produced
Important Enzymes: Substrate Entry, Energy Production, & Regulation of Flux
- Citrate Synthase
- Isocitrate Dehydrogenase
- Alpha-Ketoglutarate Dehydrogenase
- Succinate Dehydrogenase
- Malate Dehydrogenase
- Puvate Dehdogease ot a TCA eze
Directly produce energy or are involved in a reaction
Citrate Synthase
- Controls entry of substrate into TCA cycle
- Max activity correlated with VO2 max
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Document Summary

Tricarboxylic acid cycle, aka k(cid:396)e(cid:271)(cid:859)s c(cid:455)(cid:272)le, aka citric acid cycle. Metabolizes acetyl-coa produced from all three macronutrient pathways. (cid:1006)x fo(cid:396) ea(cid:272)h 6c glu(cid:272)ose o(cid:396) (cid:858)glu(cid:272)ose f(cid:396)o(cid:373) gl(cid:455)(cid:272)oge(cid:374)(cid:859) (cid:373)ole(cid:272)ule. X times for each fatty acid (variable length carbon chain) Use as a biochemical marker of aerobic capacity. Produces co2 and first nadh + h+ Produces co2 and another nadh + h+ Gtp is converted to atp (same thing) Important enzymes: substrate entry, energy production, & regulation of flux. Directly produce energy or are involved in a reaction. Controls entry of substrate into tca cycle. Max activity correlated with vo2 max the whole process in which it takes acetyl-coa. A-ketoglutarate seems a likely candidate as a maximal flux is closest to tca maximal flux (cid:894)(cid:862)(cid:396)ate li(cid:373)iti(cid:374)g e(cid:374)z(cid:455)(cid:373)e(cid:863)(cid:895) May help control maximal tca cycle flux by limiting entry of acetyl-coa (substrate) remember substrate is required for a reaction to proceed: no acetyl coa + no tca cycle flux.

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