KINE 2P97 Lecture Notes - Lecture 16: Citric Acid Cycle, Phosphofructokinase, Glycogen
8 May 2018
School
Department
Course
Professor
KINE 2P97
Muscle Physiology & Exercise Metabolism
Aging
- mitochondrial DNA damage with age
- apoptosis (death of muscle cells)
Power = F x V
- training
o ax V ist affected
o inc. max force possible
o velocity increase at submaximal loads
o increase the # of sarcomeres in parallel (hypertrophy) and in series
o parallel would be stronger but series would be faster
Adaptations for Training
Endurance training
- inc. max. aerobic capacity
- health outcomes
- improving performance
- frequency ~3-5x/w
- ~50-80% VO2 max
- Prolonged and continuous
- SAID principle: Adaptations in muscle gene expression
- Glycogen sparing
Oxygen consumption
- Delivery (lungs to blood)
- Extraction (blood to mitochondria)
- Aerobic pathway machinery
- Inc. capillary density (# of) inc. the amount of time to remove oxygen and more total
blood flow
- Increased Capillarization
Resistance training – muscular endurance
- Continuous aerobic exercise resistance training with high repetitions
Mitochondria
- Increased number and size
- More oxidative enzymes
- Always be mitch match in capabilities of type I and II
o Only one way change
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Document Summary
Said principle: adaptations in muscle gene expression. Inc. capillary density (# of) inc. the amount of time to remove oxygen and more total blood flow. Continuous aerobic exercise resistance training with high repetitions. Always be mitch match in capabilities of type i and ii: only one way change. More etc components, tca cycle, ffa oxidation & capacity to oxidize substrates. Shift to increased fat oxidation during exercise. Dec. sns activation (blunting: e and ne, cho mobilization. Inc. total amount of muscle when inc. mitochondria. Demonstrate improvements in power output and exercise. Moderate type i: all recruited during this type of exercise, typical endurance exercise may not recruit largest/fastest mu. Changes in anaerobic capacity, are much less profound than in the oxidative enzymes. We can increase our oxidative capacity to a much larger extent than anaerobic. Inc. in peak power output, total work, vo2 max, ck, hex, pfk, ldh, cs, sdh, mdh. Buffering capacity: tolerance/management of elevated lactate.
