PSYC 3F20 Lecture 19: PSYC 3F20 March 7th Bipolar
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Section 1 march 7th, 2017. w/ = with b/w = between w/o = without ppl = people q = question ps = participant. Lecture 18 ex. , or eg. , = example ie. , = in other words. Emotion regulation: hpa axis, hippocampus, and negative feedback. Cortisol (stress hormone) released by hpa axis. Negative feedback from hippocampus regulates cortisol levels (like a thermostat) Hpa axis and depression: another problem with emotion regulation. Cortisol levels are elevated in individuals with depression (barlow et al. , 2013). May be due to dysfunctional negative feedback function in hippocampus (broken thermostat) Post-mortem analyses of hippocampus showed that abused suicide victims had less transcription of genes that code for cortisol receptors compared to non-suicide comparison participants (mcgowan et al. , 2009). Healthy girls whose mothers are depressed have shown reduced hippocampal volume (chen et al. , 2010) Chronic stress and exposure to cortisol leads to atrophy of hippocampal cells and reduced hippocampal volume (herbert et al. , 2006).
