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SCIE 1P51 (142)
Lecture

Gene therpy

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Department
Science
Course
SCIE 1P51
Professor
Caroline Starrs
Semester
Winter

Description
227 Gene Therapy February2712 1056 AM In vivo Vector and GenePlasmid administered directly to organism and transfers genetic information to organism cells in vivo Ex Vivo Vector and GenePlasmid used to transfer genetic information to cells ex vivo or in vitro then cells are administered to the organism Gene therapy 1st Successful experiment 1990 Ashanti DeSilva SCID Severe Combined ImmunoDeficiency Recessive disease Vector mouse retrovirus Jesse Gelsinger 1999 18 years old Genetic liver disorder University of Pennsylvania Volunteered for clinical trial adenoviral vector caused massive immune response organ failure and death within 4 days all
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