BIOC 3101 Lecture Notes - Lecture 1: Pyruvate Carboxylase, Cori Cycle, Gluconeogenesis
Document Summary
Calculate the number of atp equivalents that would be used or generated to store 1000 glucose molecules as glycogen in a muscle cell and then metabolize it to pyruvate in the same cell. Calculate the number of atp equivalents that would be used or generated to store 1000 glucose molecules as glycogen in a liver cell and then metabolize it to pyruvate in a muscle cell. Note that phosphorylated sugars cannot enter the blood stream: storing glucose as glycogen then metabolising it generates less atp than directly metabolizing glucose. Explain the benefit of this apparently wasteful process: the cori cycle allows muscle cells to continue producing atp required for muscle contraction when glucose, glycogen, and o2 have been depleted during rigorous exercise. However, when considering the catabolism of glucose through glycolysis, and the anabolism of glucose through gluconeogenesis, the cori cycle has a net loss of 4 atp per glucose molecule.
