BIOL 1010 Lecture Notes - Lecture 4: Genbank, Ethidium Bromide, Dna Ligase
24 Feb 2014
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Tuesday, october 5, 2010 single gene disorder- mutation in single gene (cystic fibrosis, huntington"s, etc. ) a lot of human diseases are polygenic: heart disease, cancer, stroke, hypertension. Height, skin colour, eye colour, etc- controlled by many genes. A lot of mutation are lethal (in utero- die before birth) Can have them generation to generation or spontaneous. Incomplete penetrance- mutation could be masked by other alleles interacting. Expressivity- two people with parkinson"s could exhibit different symptoms. Darp- gene that was turned off for mice- brain gene that also affected kidneys, Pleiotropy- gene influences several aspects of the phenotype females wouldn"t do ordosis (stick butt up when in heat) Lots of important traits on x-chromosome, lots of x-linked diseases. Linkage- genes on same chromosome- genes tend to move together- can see inheritance patterns very clearly. Alzheimer"s called the swedish mutation because of particular swedish family.
