BIOL 1103 Lecture Notes - Interleukin 5, Complement Component 5A, Interleukin 3

28 views3 pages
30 Jan 2013
Department
Course
Professor
IMMEDIATE HYPERSENSITIVTY REACTIONS
Type I Hypersensitivity/ Allergic Reactions
Nomenclature:
Allergen = antibody that elicits an IgE (REAGIN) response
- can be inhaled, ingested, or injected
- small proteins or chemicals bound to proteins
- very soluble
- they display SENSITIZATION (previous exposure elicits a reaction)
Allergy = clinical manifestations of reaction
ATOPY = genetic predisposition to make IgE’s
Immediate Skin Response = WHEAL and FLARE
IgER’s (FcER’s)
RI – high affinity binding (mast cells, basophils)
tetramer (abg2); beta and gamma domains have ITAM motifs
trimeric version (no beta) – found in monocytes and DC’s
UPREGULATED BY IgE PRESENCE
RII – low affinity binding; also called CD23
2 isoforms; neither is homologous to FcERI
CONTROL OF IgE SYNTHESIS: 2 SIGNAL HYPOTHESIS
2 SIGNALS work on B – cells
1. IL4/IL13 from Th2 cells, Basophils, and Mast Cells
**activates E gene transcription**
occurs via JAK/STAT6 pathway
2. CD40/CD40L binding between B and Th2 Cells
**activates switch recombination**
Secreted IgE’s bind to Mast Cells
Crosslinking by allergen causes degranulation, tyrosine kinase activity
Unlock document

This preview shows page 1 of the document.
Unlock all 3 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.