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BIOL 1103 (33)
Lecture

Immunoglobulins

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Department
Biology
Course
BIOL 1103
Professor
Tamy Superle
Semester
Fall

Description
Outline of Lecture 02 Immunoglobulins I, Structure and Function I. Innate vs. Adaptive Immunity A. Innate immunity: quick response to general invariant microbe features B. Adaptive immunity: delayed response to diverse antigens, highly specific II. Features of Adaptive Immunity A. B and T lymphocytes mediated B. B cells produce antibody, recognize Ag outside of cells 1. Soluble antibody serves… To neutralize viruses and toxins To facilitate phagocytosis (opsonization) To activate complement 2. Membrane bound antibody activates lymphocytes mediates Ag uptake for presentation by T cells C. T cells have TCR, can recognized Ag expressed inside cells D. Clonal selection theory: random Ab diversity and clonal expansion E. Memory causes secondary response to be faster and more specific III. Antibody Structure A. Heavy chains 50 kDa variable (VH) and constant (CH1-3) regions μ, δ, γ, α, ε chains corresponding to Ab class B. Light chains 25 kDa variable (VL) and constant (L ) regions κ (major), λ chains C. Other
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