BIOL 1103 Lecture Notes - Mast Cell, Complement System, Immunoglobulin M
30 Jan 2013
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Document Summary
Produced by epithelia, acts as iga receptor, transcytoses it. Sc1 domain non-covalently interacts with iga/j, sc5 covalently links to. Prevents proteolysis of iga by self and pathogens: across placenta: igg is actively transported across placenta to fetus via fc. Ha and na coat glycoproteins are responsible for attachment and. Viral strains can be distinguished by antigenically different ha and na: mechanisms of neutralization by ab, inhibit binding of virus to target cells (sterically block na, inhibit virus from entering cell, inhibit endocytic vessel fusion necessary for infection. Inflammatory activities (4 items: opsonization fashion, complement. Ag binds bacteria; fc receptors by ab; particle is phagocytosed in zipper: activation of mast cells. Igm or crosslinked igg activate c1q, which starts complement cascade. Complement forms a porin in bacterial cell wall causing lysis. Mediated by ige bound to fc receptors on mast cells. Crosslinking ige causes degranulation and phospholipase a2 activation.
