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BIOL 2005 (40)

Helper Cell Effector Functions

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Carleton University
BIOL 2005
Elizabeth Nisbet

CD4 T-HELPER CELL EFFECTOR FUNCTIONS antigen recognition does not occur at site of entry, but usually in lymph nodes/spleen activated T cells then migrate to target tissues T-CELL PROLIFERATION IL2R – complex of αβγ that associate non-covalently essential for immune function, as its chains are involved in MANY ILR’s IL2 is not absolutely necessary b/c other cytokines can replace function ag:MHC complex binding to TCR triggers IL2R assembly/synthesis ensures that IL2 only activates clonal expansion of ag-specific cells ag:MHC complex binding to TCR can also stimulate IL2 SYNTHESIS some cells can make IL2  autocrine/endogenous can be used can’t make IL2  paracrine/exogenous IL2 necessary other IL’s IL4 – growth factor, similar to IL2 IL7 – growth factor for immature T cells (CD4-, CD8-) in thymus produced by thymus stromal cells ILR’s are coupled to tyrosine kinases Jaks phos. STATs (TF’s) CD4 CELL SUBCLASSES TH1 – synthesize IL2/3, TNFα, γ-INTERFERON activates macrophages and enhances their ability to kill ingested microbes (bacteria, fungi, protozoa) 1) γ-inteferon is released in response to macrophage MHC II antigen presentation 2) CD40 (macrophage) binds CD40L(T cell) and/or TNF (T cell) interacts with TNF-R (macrophage) these combined enhance macrophage lysosome-phagosome fusion enhanced macro
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