BIOL 2005 Lecture Notes - Interleukin 4, T Helper Cell, Glycolipid

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30 Jan 2013
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NATURAL KILLER CELLS
part of innate immunity; no prior exposure is necessary
anti viral, anti-tumor, transplant rejection, materno-fetal interaction roles
protection during T-cell priming period
from CD34+ precursors; IL15-driven maturation in bone marrow
NK CELLS RECOGNITION
1) ANTIBODY (IgG)
2) ADHESION
3) NON-MHCI expressing cells
**NK cells are unique in that they will lyse donor cells NOT expressing
ALL host MHCI haplotypes**
NK CELLS vs. T CELLS
NK – constitutive expression of lytic machinery
MHC recognition INHIBITS lysis
no activation necessary (by cytokines for example)
can release inflammatory cytokines (IFN-g, TNF-b, GM-CSF) TH1 act.
anti-tumor roles
perforin-lysis
no antigen recognition
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