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BIOL 2005 (40)
Lecture

Cell Tolerance and Development Tolerance

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Department
Biology
Course
BIOL 2005
Professor
Elizabeth Nisbet
Semester
Fall

Description
T CELL TOLERANCE AND DEVELOPMENT TOLERANCE – unresponsiveness to a particular ag (usually self) self-tolerance is learned by developing immune system FREEMARTIN condition in twin cattle: BURNET hypothesis dizygotic twins sharing a placenta will therefore share RBC’s developing/immature lymphocytes are subject to CLONAL DELETION in presence if self-antigens are recognized must occur during fetal development or early neonatal period after that, ability to become tolerance falls off RAPIDLY T-CELLS – more important than B-cells for tolerance Central Tolerance – generated during lymphocyte development involves clonal deletion Peripheral Tolerance – generated AFTER lymphocytes have matured involves ANERGY (inactivation) T-CELL DEVELOPMENT: occus in thymus in 3 stages 1) TCR gene rearrangments resulting in productive α/β dimers on cell surface α/β have many more V/J segments than γ/δ δ is located within α this prevents α/β and γ/δ co-expression 1. V/J rearrangements in α/β an
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