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BIOL 2005 (40)
Lecture

Immune Activation vs Tolerance

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Department
Biology
Course
BIOL 2005
Professor
Elizabeth Nisbet
Semester
Fall

Description
T CELL TOLERANCE Immune activation vs. tolerance is CIRCUMSTANCE driven Janeway: immune system responds to antigen + presence of PAMP/PRR int. no PAMP/PRR interaction  tolerance Matzinger: “DANGER” theory – antigens presented during danger lead to immune system response danger = release of necrotic cell proteins (HSP’s) **both mechanisms involve APC activation** APC’s present antigen AND release co-stimulatory molecules MECHANISMS OF T-CELL TOLERANCE THYMUS – positive selection: only T cells that can interact with self-MHC’s will mature negative selection: if binding to peptide:MHC complex is too tight  deletion **unlikely that ALL self antigens are present in thymus during dev.** PERIPHERAL TOLERANCE: Mechanisms IGNORANCE – T-cells are potentially autoreactive but not enough antigen is present to elicit a response CLONAL DELETION – high amount of
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