BIOL 2005 Lecture Notes - Interleukin 10, Immunoglobulin A, Cytokine
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T CELL TOLERANCE
Immune activation vs. tolerance is CIRCUMSTANCE driven
Janeway: immune system responds to antigen + presence of PAMP/PRR int.
no PAMP/PRR interaction tolerance
Matzinger: “DANGER” theory – antigens presented during danger lead to
immune system response
danger = release of necrotic cell proteins (HSP’s)
**both mechanisms involve APC activation**
APC’s present antigen AND release co-stimulatory molecules