BIOL 2104 Lecture Notes - Lecture 9: Long Non-Coding Rna, Non-Coding Rna, Epigenome
14 Feb 2019
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Document Summary
Regulation of gene expression in eukaryotes (epigenetics: during its life span, an organism has one genome, this genome can be modified in diverse cell types at different times, produces many epigenomes, epigenetics implicated in . Progressive restriction of gene expression during development. Environment genome interactions during prenatal development that affect adult phenotypes. Epigenome refers to epigenetic state of a cell. Epigenetic trait stable, mitotically and meiotically heritable phenotype that results from changes in gene expression without alterations in the dna sequence. Participate in epigenetic regulation of gene expression. Molecules associate with protein complexes to form rna-induced silencing (riscs) Modulates gene expression lncrna (long non-coding rna) 5"-caps, 3" poly-a tails, splicing of introns. Classes of loci: antisense, intronic, bidirectional, intergenic. Decoy lncrna competes for transcription initiation sites. Adapter lncrnas act as adapters to bring multiple proteins together to form a complex. Guide lncrna brings complexes to specific loci.
