BIOL 2107 Lecture Notes - Lecture 14: Adenine, Photolyase, Colorectal Cancer

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Mutations are heritable changes in dna base sequences: mutations must go to the next generation. Forward mutation changes wild-type allele to a different allele. i. e. a+ a or b+ b. Forward mutation changes wild-type allele to a different allele. i. e. a+ a or b+ b i. e. a a+ or b b: forward is generally dominant. Reverse mutation (reversion) changes a mutant allele back to wild type: recessive mutation, will change to the dominant one. Forward mutation rate is usually greater than reversion rate. Forward"s usually greater because we have lots of wildtypes, and they are prone to change. Classification of mutations by effect on dna molecule. Substitution replacement of a base by another base: transition purine replaced by another purine, or pyrimidine replaced by another pyrimidine, transversion purine replaced by a pyrimidine, or pyrimidine replaced by a purine. Deletion block of 1 or more bp lost from dna. Insertion block of 1 or more bp added to dna.

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